Science
I currently work as a scientist in a start up company that aims to harness the predictive power of epigenetics and turn it into personalized tools for health and disease prevention.
During my career, I have worked with a wide range of organisms. For my PhD, I studied a non model organism called Schizosaccharomyces japonicus, a microscopic fission yeast and a distant cousin of model Schizosaccharomyces pombe. I had two main goals: set up a toolbox to use S. japonicus routinely in my (S. pombe centric) lab and investigate the curious and dimorphic growth behavior of my favorite yeast.
S. japonicus growing as a fission yeast.
Scale bar: 10µm. An image every 10min.
S. japonicus growing as a filamentous organism.
Scale bar: 10µm. An image every 5min.
Before that, during my master, I worked with primary human macrophages and studied the morphological changes following an HIV-1 infection. My study focused on cytoskeleton and migration changes.
I am fascinated with the interface that exists between organisms and their environment, what exists between life and non-life. How organisms adapt, evolve & transform their surroundings and how the environment shapes evolution .
Publications
Chamberlain JD, Nusslé S, Chapatte L, Kinnaer C, Petrovic D, Pradervand S, Bochud M, Harris SE, Corley J, Cox SR, Gonseth Nusslé S. (2022). Blood DNA methylation signatures of lifestyle exposures: tobacco and alcohol consumption. Clin Epigenetics,14(1):155. https://doi.org/10.1186/s13148-022-01376-7
Kinnaer, C., Dudin, O., & Martin, S. G. (2019). Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to environmental stimuli. Molecular Biology of the Cell, 30(8), 975–991. https://doi.org/10.1091/mbc.e18-12-0774
Vérollet, C., Souriant, S., Bonnaud, E., Jolicoeur, P., Raynaud-Messina, B., Kinnaer, C., Fourquaux, I., Imle, A., Benichou, S., Fackler, O. T., Poincloux, R., & Maridonneau-Parini, I. (2015). HIV-1 reprograms the migration of macrophages. Blood, 125(10), 1611–1622. https://doi.org/10.1182/blood-2014-08-596775